Curcuma longa supplement increases anxiety-like behavior and blood glucose level in Swiss albino mice

Authors

  • Usman Adamu Garkuwa (1) Department of Physiology, Faculty of Basic Medical Sciences, Bauchi State University Gadau, Bauchi State, Nigeria. (2) Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University Zaria, Nigeria.
  • Buhari Ibrahim Department of Physiology, Faculty of Basic Medical Sciences, Bauchi State University Gadau, Bauchi State, Nigeria.
  • Aisha Nasir Balanmalam Department of Physiology, Faculty of Basic Medical Sciences, Bauchi State University Gadau, Bauchi State, Nigeria.
  • Sayyadatu Razan Muhammad Department of Physiology, Faculty of Basic Medical Sciences, Bauchi State University Gadau, Bauchi State, Nigeria.
  • Mustapha Muazu Department of Physiology, Faculty of Basic Medical Sciences, Bauchi State University Gadau, Bauchi State, Nigeria.
  • Adamu Hassan Garkuwa Abubakar Tafawa Balewa University Teaching Hospital Bauchi, Bauchi State, Nigeria.
  • Adamu Bello Yakubu (1) Department of Physiology, Faculty of Basic Medical Sciences, Bauchi State University Gadau, Bauchi State, Nigeria. (2) Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University Zaria, Nigeria.

DOI:

https://doi.org/10.31117/neuroscirn.v4i1.60

Keywords:

anxiety-like behavior, blood glucose, depression, Curcuma longa

Abstract

Curcuma longa (C. longa), also known as curcumin, is a lipophilic polyphenol substance proven to have cholesterol-lowering, anti-diabetic, anti-inflammatory, anti-oxidant, and anti-cancer properties in both in vitro and in vivo models. Most previous studies investigated the effect of C. longa on diabetic mice and therefore, there is a need to investigate the effect of C. longa on normoglycemic mice. Depression is a common consequence of anxiety that affects 21% of the world’s population. Since the prevalence of diabetes and depression is on the rise globally, it is important to search for safer and cost-effective management for these disorders. In doing so, it is therefore essential to investigate its effect in normoglycemic mice. The current study determines the effect of C. longa on blood glucose level and anxiety-like behavior in normoglycemic Swiss albino mice. A total of 20 mice were divided into four groups of five (n=5 per group). Group I (control) received distilled water 10 ml/kg, groups II, III, and IV received C. longa at 5%, 10%, and 20%, respectively, for 14 days. We found that 20% C. longa group showed a significant (p<0.05) increase in fasting blood glucose level (195.84±14.46 mg/dl) after 14 days of administration compared with the control group (134.60±4.52 mg/dl).  We also found that 20% C. longa increased the anxiety-like behavior in normoglycemic Swiss albino mice compared with the control group. However, there was no significant (p>0.05) difference in both fasting blood glucose level and anxiety-like behavior between the mice treated with 5% and 10% C. longa and the control group. This study indicates that C. longa at high concentration is unsafe for consumption by normoglycemic Swiss albino mice.

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Published

2021-02-26

How to Cite

Garkuwa, U., Ibrahim, B., Balanmalam, A., Muhammad, S., Muazu, M., Garkuwa, H. and Yakubu, A. (2021) “Curcuma longa supplement increases anxiety-like behavior and blood glucose level in Swiss albino mice”, Neuroscience Research Notes, 4(1), pp. 1–6. doi: 10.31117/neuroscirn.v4i1.60.

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Research Notes