Neuroscience Research Notes https://neuroscirn.org/ojs/index.php/nrnotes A high quality, free open access and peer-reviewed journal from scientists to scientists. Neurotak Publishing (BC0008786-U) en-US Neuroscience Research Notes 2576-828X <p>The observations and associated materials published or posted by NeurosciRN are licensed by the authors for use and distribution in accord with the <a href="https://creativecommons.org/licenses/by-nc/4.0/" target="_blank" rel="external noopener">Creative Commons Attribution license CC BY-NC 4.0 international</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p> Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders https://neuroscirn.org/ojs/index.php/nrnotes/article/view/28 <p>The human brain is made up of billions of neurons and glial cells which are interconnected and organized into specific patterns of neural circuitry, and hence is arguably the most sophisticated organ in human, both structurally and functionally. Studying the underlying mechanisms responsible for neurological or neurodegenerative disorders and the developmental basis of complex brain diseases such as autism, schizophrenia, bipolar disorder, Alzheimer’s and Parkinson’s disease has proven challenging due to practical and ethical limitations on experiments with human material and the limitations of existing biological/animal models. Recently, cerebral organoids have been proposed as a promising and revolutionary model for understanding complex brain disorders and preclinical drug screening.</p> Pike-See Cheah John O. Mason King Hwa Ling ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 2019-01-12 2019-01-12 2 1 1 6 10.31117/neuroscirn.v2i1.28