Neuroscience Research Notes A high quality, free open access and peer-reviewed journal from scientists to scientists. en-US <p>The observations and associated materials published or posted by NeurosciRN are licensed by the authors for use and distribution in accord with the <a href="" target="_blank" rel="external noopener">Creative Commons Attribution license CC BY-NC 4.0 international</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p> (Connie Ling) (Connie Ling) Sun, 30 Dec 2018 00:00:00 +0800 OJS 60 Ultrastructural study of sciatic nerve in Ts1Cje mouse model for Down syndrome: an implication of peripheral nerve defects in hypotonia <p>Trisomy 21 is chromosomal abnormality that occurs as a result of triplication of human chromosome 21 (Hsa21), a condition also known as Down syndrome (DS). Beside the intellectual disability and systems anomalies, motor dysfunction due to hypotonia has also been characterised in individuals with DS and yet, its aetiology remains unclear. Ts1Cje, a mouse model for DS, has a partial trisomy (<em>Mmu16)</em> homology to Hsa21, is widely used for DS research. This study investigated the morphological changes and degree of myelination in sciatic nerves of the Ts1Cje mice using both light and transmission electron microscopes processed images. The result showed no morphological difference in the sciatic nerve between the Ts1Cje and WT mice. The g ratio of the Ts1Cje mice was significantly (<em>P&lt;</em>0.0001) higher compared to that of the WT mice. Two factors are known to determine the g ratio, the axonal diameter and the myeline thickness. There was no significant (<em>P=</em>0.2146) difference in the axonal diameter between the two genotypes. Interestingly, the myeline thickness was significantly (<em>P&lt;</em>0.0001) thinner in nerve fibres of the Ts1Cje mice as compared to that of the WT mice. It is therefore concluded that, the hypomyelination in Ts1Cje mice may affect the conduction velocity which in turn affect their motor activity.</p> Usman Bala, Melody Pui-Yee Leong, Chai Ling Lim, Hayati Kadir Shahar, Othman Fauziah, Mei I Lai, King-Hwa Ling, Pike-See Cheah ##submission.copyrightStatement## Tue, 16 Oct 2018 00:00:00 +0800