Neuroscience Research Notes https://neuroscirn.org/ojs/index.php/nrnotes A high quality, free open access and peer-reviewed journal from scientists to scientists. en-US <p>The observations and associated materials published or posted by NeurosciRN are licensed by the authors for use and distribution in accord with the <a href="https://creativecommons.org/licenses/by-nc/4.0/" target="_blank" rel="external noopener">Creative Commons Attribution license CC BY-NC 4.0 international</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p> info@neuroscirn.org (Connie Ling) info@neuroscirn.org (Connie Ling) Sun, 30 Dec 2018 00:00:00 +0800 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Ultrastructural study of sciatic nerve in Ts1Cje mouse model for Down syndrome: an implication of peripheral nerve defects in hypotonia https://neuroscirn.org/ojs/index.php/nrnotes/article/view/17 <p>Trisomy 21 is chromosomal abnormality that occurs as a result of triplication of human chromosome 21 (Hsa21), a condition also known as Down syndrome (DS). Beside the intellectual disability and systems anomalies, motor dysfunction due to hypotonia has also been characterised in individuals with DS and yet, its aetiology remains unclear. Ts1Cje, a mouse model for DS, has a partial trisomy (<em>Mmu16)</em> homology to Hsa21, is widely used for DS research. This study investigated the morphological changes and degree of myelination in sciatic nerves of the Ts1Cje mice using both light and transmission electron microscopes processed images. The result showed no morphological difference in the sciatic nerve between the Ts1Cje and WT mice. The g ratio of the Ts1Cje mice was significantly (<em>P&lt;</em>0.0001) higher compared to that of the WT mice. Two factors are known to determine the g ratio, the axonal diameter and the myeline thickness. There was no significant (<em>P=</em>0.2146) difference in the axonal diameter between the two genotypes. Interestingly, the myeline thickness was significantly (<em>P&lt;</em>0.0001) thinner in nerve fibres of the Ts1Cje mice as compared to that of the WT mice. It is therefore concluded that, the hypomyelination in Ts1Cje mice may affect the conduction velocity which in turn affect their motor activity.</p> Usman Bala, Melody Pui-Yee Leong, Chai Ling Lim, Hayati Kadir Shahar, Othman Fauziah, Mei I Lai, King-Hwa Ling, Pike-See Cheah ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://neuroscirn.org/ojs/index.php/nrnotes/article/view/17 Tue, 16 Oct 2018 00:00:00 +0800 Post spinal meningitis with subdural collection: an uncommon complication after spinal anaesthesia for caesarean section https://neuroscirn.org/ojs/index.php/nrnotes/article/view/18 <p>Meningitis after spinal anaesthesia is a rare yet devastating complication of spinal anaesthesia. The exact incidence is unknown. Our patient developed signs and symptoms of meningitis 48 hours after spinal anaesthesia and required intensive care unit admission. Her cerebrospinal fluid was sterile. Computed tomography of brain showed left subdural collection. She recovered well after 6 weeks of intravenous antibiotics. No neurological sequela noted from subsequent follow-up examinations. Our case provides an important insight of meningitis with subdural collection after spinal anaesthesia for emergency caesarean section.</p> Seng Wee Cheo, Qin Jian Low, Yee Ann Tan, Yuen Kang Chia ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://neuroscirn.org/ojs/index.php/nrnotes/article/view/18 Wed, 24 Oct 2018 00:00:00 +0800 Malaysian Society of Neurosciences (MSN) – Asian and Oceanian Myology Centre (AOMC) Annual Scientific Meeting 2018 https://neuroscirn.org/ojs/index.php/nrnotes/article/view/23 <p>The conjoint 17<sup>th</sup> Asian and Oceanian Myology Centre (AOMC) and 28<sup>th</sup> Malaysian Society of Neurosciences (MSN) Annual Scientific Meeting, held in Hotel Istana, Kuala Lumpur, Malaysia from 27 to 29 July 2018, was a great success to gather all neurosciences professionals locally and in the Asian-Oceanian region to share the latest updates in Neurology and specifically Myology. This congress attracted 516 local participants and 167 international delegates from 14 countries.&nbsp;</p> <p>&nbsp;</p> Kheng Seang Lim, Khean-Jin Goh, Ai-Huey Tan, Mustapha Muzaimi, Soon-Chai Low ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://neuroscirn.org/ojs/index.php/nrnotes/article/view/23 Thu, 20 Dec 2018 00:00:00 +0800