Interleukin 1 receptor antagonist and neurodegenerative diseases: the future treatment strategy
DOI:
https://doi.org/10.31117/neuroscirn.v6i1.164Keywords:
interleukin 1, Interleukin 1 receptor antagonist, Neurodegeneration, Neuroinflammation, CNSAbstract
Neurodegenerative disorders encompass a range of conditions affecting the central nervous system (CNS) in which alterations in the neuronal structure and cellular dysfunction lead to progressive deterioration. Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the CNS have become almost synonymous with neuroinflammation. Additionally, the relentless activation of the IL-1 signalling pathway has been linked with the pathogenesis of various CNS disease states, ranging from Alzheimer disease (AD), Parkinson disease (PD) to amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). Moreover, a growing body of evidence has inferred that impeding the IL-1 signalling either pharmacologically or genetically in various CNS disease models could reduce neuroinflammation or delay disease progression. This review will therefore aim to study the role of IL-1 in neurodegenerative diseases and highlight the key aspects that warrant IL-1Ra as a promising target for developing a novel treatment for various CNS conditions.
References
Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W. S., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I. R., McGeer, P. L., O'Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Van Muiswinkel, F. L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., & Wyss-Coray, T. (2000). Inflammation and Alzheimer's disease. Neurobiology of Aging, 21(3), 383-421. https://doi.org/10.1016/s0197-4580(00)00124-x
Allan, S., & Rothwell, N. (2001). Cytokines and acute neurodegeneration. Nature Reviews Neuroscience, 2, 734-744. https://doi.org/10.1038/35094583
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005). Interleukin-1 and neuronal injury. Nature Reviews Immunology, 5(8), 629-640. https://doi.org/10.1038/nri1664
Arend, W. P. (2002). The balance between IL-1 and IL-1Ra in disease. Cytokine & Growth Factor Reviews, 13(4-5), 323-340. https://doi.org/10.1016/s1359-6101(02)00020-5
Basu, A., Krady, J. K., & Levison, S. W. (2004). Interleukin-1: A master regulator of neuroinflammation. Journal of Neuroscience Research, 78(2), 151-156. https://doi.org/https://doi.org/10.1002/jnr.20266
Bellinger, F. P., Madamba, S., & Siggins, G. R. (1993, Nov 19). Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus. Brain Research, 628(1-2), 227-234. https://doi.org/10.1016/0006-8993(93)90959-q
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987, Oct 23). Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science, 238(4826), 524-526. https://doi.org/10.1126/science.2443979
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986, Aug 8). Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science, 233(4764), 652-654. https://doi.org/10.1126/science.3014662
Braddock, M., & Quinn, A. (2004, Apr). Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention. Nature Reviews Drug Discovery, 3(4), 330-339. https://doi.org/10.1038/nrd1342
Cao, J., Semenova, M. M., Solovyan, V. T., Han, J., Coffey, E. T., & Courtney, M. J. (2004). Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. Journal of Biological Chemistry, 279(34), 35903-35913. https://doi.org/10.1074/jbc.M402353200
Chakrabarti, S., Prorok, T., Roy, A., Patel, D., Dasarathi, S., & Pahan, K. (2021). Upregulation of IL-1 Receptor Antagonist by Aspirin in Glial Cells via Peroxisome Proliferator-Activated Receptor-Alpha. Journal of Alzheimer's Disease Reports, 5, 647-661. https://doi.org/10.3233/ADR-210026
Cunningham, E. T., Jr., Wada, E., Carter, D. B., Tracey, D. E., Battey, J. F., & De Souza, E. B. (1992). In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. Journal of Neuroscience, 12(3), 1101-1114. https://doi.org/10.1523/jneurosci.12-03-01101.1992
DeSena, A. D., Do, T., & Schulert, G. S. (2018). Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade. Journal of Neuroinflammation, 15(1), 38. https://doi.org/10.1186/s12974-018-1063-2
Farrar, W. L., Kilian, P. L., Ruff, M. R., Hill, J. M., & Pert, C. B. (1987). Visualization and characterization of interleukin 1 receptors in brain. Journal of Immunology, 139(2), 459-463.
Garber, C., Vasek, M. J., Vollmer, L. L., Sun, T., Jiang, X., & Klein, R. S. (2018). Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1. Nature Immunology, 19(2), 151-161. https://doi.org/10.1038/s41590-017-0021-y
Glaccum, M. B., Stocking, K. L., Charrier, K., Smith, J. L., Willis, C. R., Maliszewski, C., Livingston, D. J., Peschon, J. J., & Morrissey, P. J. (1997). Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. Journal of Immunology, 159(7), 3364-3371.
González-Scarano, F., & Baltuch, G. (1999). Microglia as mediators of inflammatory and degenerative diseases. Annual Review of Neuroscience, 22, 219-240. https://doi.org/10.1146/annurev.neuro.22.1.219
Gosselin, D., & Rivest, S. (2007). Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system. Brain Behavior and Immunity, 21(3), 281-289. https://doi.org/10.1016/j.bbi.2006.12.004
Griffin, W. S., Sheng, J. G., Gentleman, S. M., Graham, D. I., Mrak, R. E., & Roberts, G. W. (1994a). Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression. Neuroscience Letters, 176(2), 133-136. https://doi.org/10.1016/0304-3940(94)90066-3
Griffin, W. S., Sheng, J. G., Gentleman, S. M., Graham, D. I., Mrak, R. E., & Roberts, G. W. (1994b). Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression. Neuroscience letters, 176(2), 133-136. https://doi.org/10.1016/0304-3940(94)90066-3
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V., Perrot, L. J., White, C. L., 3rd, & Araoz, C. (1989). Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of USA, 86(19), 7611-7615. https://doi.org/10.1073/pnas.86.19.7611
Griffiths, M., Neal, J. W., & Gasque, P. (2007). Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. International Review of Neurobiology, 82, 29-55. https://doi.org/10.1016/s0074-7742(07)82002-2
Haddad, J. J., Saadé, N. E., & Safieh-Garabedian, B. (2002). Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis. Journal of Neuroimmunology, 133(1-2), 1-19. https://doi.org/10.1016/s0165-5728(02)00357-0
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., Gelpi, E., Halle, A., Korte, M., Latz, E., & Golenbock, D. T. (2013). NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature, 493(7434), 674-678. https://doi.org/10.1038/nature11729
Huang, Y., Smith, D. E., Ibáñez-Sandoval, O., Sims, J. E., & Friedman, W. J. (2011). Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein. Journal of Neuroscience, 31(49), 18048-18059. https://doi.org/10.1523/jneurosci.4067-11.2011
Ishida, Y., Kondo, T., Kimura, A., Matsushima, K., & Mukaida, N. (2006). Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway. Journal of Immunology (Baltimore, Md. : 1950), 176(9), 5598-5606. https://doi.org/10.4049/jimmunol.176.9.5598
Katsuki, H., Nakai, S., Hirai, Y., Akaji, K., Kiso, Y., & Satoh, M. (1990). Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. European Journal of Pharmacology, 181(3), 323-326. https://doi.org/10.1016/0014-2999(90)90099-r
Khazim, K., Azulay, E. E., Kristal, B., & Cohen, I. (2018). Interleukin 1 gene polymorphism and susceptibility to disease. Immunological Reviews, 281(1), 40-56. https://doi.org/10.1111/imr.12620
Koo, J. W., & Duman, R. S. (2009). Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Current Opinion in Investigational Drugs, 10(7), 664-671.
Kwon, H. S., & Koh, S.-H. (2020). Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Translational Neurodegeneration, 9(1), 42. https://doi.org/10.1186/s40035-020-00221-2
Lin, M. T., Kao, T. Y., Jin, Y. T., & Chen, C. F. (1995). Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats. Brain Research Bulletin, 37(6), 595-598. https://doi.org/10.1016/0361-9230(95)00046-h
Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., Gorantla, G., Oliver, B., Witcher, K. G., Wang, Y., Negray, C. E., Vegesna, R. S., Sheridan, J. F., Godbout, J. P., Robson, M. J., Blakely, R. D., Popovich, P. G., Bilbo, S. D., & Quan, N. (2019). Cell-type-specific interleukin 1 receptor 1 signaling in the brain regulates distinct neuroimmune activities. Immunity, 50(2), 317-333.e316. https://doi.org/10.1016/j.immuni.2018.12.012
Liu, X., & Quan, N. (2018). Microglia and CNS interleukin-1: Beyond immunological concepts. Frontiers in Neurology, 9, 8. https://doi.org/10.3389/fneur.2018.00008
Lukens, J. R., Gross, J. M., & Kanneganti, T. D. (2012). IL-1 family cytokines trigger sterile inflammatory disease. Frontiers in Immunology, 3, 315. https://doi.org/10.3389/fimmu.2012.00315
McGuinness, M. C., Powers, J. M., Bias, W. B., Schmeckpeper, B. J., Segal, A. H., Gowda, V. C., Wesselingh, S. L., Berger, J., Griffin, D. E., & Smith, K. D. (1997). Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis. Journal of Neuroimmunology, 75(1-2), 174-182. https://doi.org/10.1016/s0165-5728(97)00020-9
Park, D. S., Stefanis, L., Yan, C. Y., Farinelli, S. E., & Greene, L. A. (1996). Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. Journal of Biological Chemistry, 271(36), 21898-21905. https://doi.org/10.1074/jbc.271.36.21898
Patel, H. C., Boutin, H., & Allan, S. M. (2003,). Interleukin-1 in the brain: mechanisms of action in acute neurodegeneration. Annals of the New York Academy of Sciences, 992, 39-47. https://doi.org/10.1111/j.1749-6632.2003.tb03136.x
Qian, J., Zhu, L., Li, Q., Belevych, N., Chen, Q., Zhao, F., Herness, S., & Quan, N. (2012). Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proceedings of the National Academy of Sciences of USA, 109(30), 12189-12194. https://doi.org/10.1073/pnas.1205207109
Relton, J. K., & Rothwell, N. J. (1992). Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Research Bulletin, 29(2), 243-246. https://doi.org/10.1016/0361-9230(92)90033-t
Ren, K., & Torres, R. (2009). Role of interleukin-1beta during pain and inflammation. Brain Research Reviews, 60(1), 57-64. https://doi.org/10.1016/j.brainresrev.2008.12.020
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004). Role of microglia in central nervous system infections. Clinical Microbiology Reviews, 17(4), 942-964. https://doi.org/10.1128/cmr.17.4.942-964.2004
Rothwell, N. (2003). Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behavior and Immunity, 17(3), 152-157. https://doi.org/10.1016/s0889-1591(02)00098-3
Rothwell, N., Allan, S., & Toulmond, S. (1997). The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. Journal of Clinical Investigation, 100(11), 2648-2652. https://doi.org/10.1172/jci119808
Rothwell, N. J., & Luheshi, G. N. (2000). Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci, 23, 618-625.
Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K. (2008). The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. Journal of neuroinflammation, 5, 7-7. https://doi.org/10.1186/1742-2094-5-7
Simi, A., Lerouet, D., Pinteaux, E., & Brough, D. (2007. Mechanisms of regulation for interleukin-1beta in neurodegenerative disease. Neuropharmacology, 52(8), 1563-1569. https://doi.org/10.1016/j.neuropharm.2007.02.011
Sims, J. E., March, C. J., Cosman, D., Widmer, M. B., MacDonald, H. R., McMahan, C. J., Grubin, C. E., Wignall, J. M., Jackson, J. L., Call, S. M., & et al. (1988). cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science, 241(4865), 585-589. https://doi.org/10.1126/science.2969618
Srinivasan, D., Yen, J. H., Joseph, D. J., & Friedman, W. (2004). Cell type-specific interleukin-1beta signaling in the CNS. Journal of Neuroscience, 24(29), 6482-6488. https://doi.org/10.1523/jneurosci.5712-03.2004
Stanley, L. C., Mrak, R. E., Woody, R. C., Perrot, L. J., Zhang, S., Marshak, D. R., Nelson, S. J., & Griffin, W. S. (1994). Glial cytokines as neuropathogenic factors in HIV infection: pathogenic similarities to Alzheimer's disease. Journal of Neuropathology and Experimental Neurology, 53(3), 231-238. https://doi.org/10.1097/00005072-199405000-00003
Streit, W. J. (2004). Microglia and Alzheimer's disease pathogenesis. Journal of Neuroscience Research, 77(1), 1-8. https://doi.org/10.1002/jnr.20093
Streit, W. J. (2006). Microglial senescence: does the brain's immune system have an expiration date? Trends in Neuroscience, 29(9), 506-510. https://doi.org/10.1016/j.tins.2006.07.001
Suescun, J., Chandra, S., & Schiess, M. C. (2019). Chapter 13 - The Role of Neuroinflammation in Neurodegenerative Disorders. In J. K. Actor & K. C. Smith (Eds.), Translational inflammation (pp. 241-267). Academic Press. https://doi.org/https://doi.org/10.1016/B978-0-12-813832-8.00013-3
Tomasoni, R., Morini, R., Lopez-Atalaya, J. P., Corradini, I., Canzi, A., Rasile, M., Mantovani, C., Pozzi, D., Garlanda, C., Mantovani, A., Menna, E., Barco, A., & Matteoli, M. (2017). Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects. Elife, 6. https://doi.org/10.7554/eLife.21735
Vezzani, A., Moneta, D., Conti, M., Richichi, C., Ravizza, T., De Luigi, A., De Simoni, M. G., Sperk, G., Andell-Jonsson, S., Lundkvist, J., Iverfeldt, K., & Bartfai, T. (2000). Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proceedings of the National Academy of Sciences of USA, 97(21), 11534-11539. https://doi.org/10.1073/pnas.190206797
Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., & Marinovich, M. (2003). Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. Journal of Neuroscience, 23(25), 8692-8700. https://doi.org/10.1523/jneurosci.23-25-08692.2003
Weber, A., Wasiliew, P., & Kracht, M. (2010). Interleukin-1 (IL-1) pathway. Science Signaling, 3(105), cm1. https://doi.org/10.1126/scisignal.3105cm1
Wong, R., Lénárt, N., Hill, L., Toms, L., Coutts, G., Martinecz, B., Császár, E., Nyiri, G., Papaemmanouil, A., Waisman, A., Müller, W., Schwaninger, M., Rothwell, N., Francis, S., Pinteaux, E., Denés, A., & Allan, S. M. (2019). Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain, Behavior, and Immunity, 76, 126-138. https://doi.org/https://doi.org/10.1016/j.bbi.2018.11.012
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