Data on multiple post-translational modifications in Alzheimer's disease

Authors

  • Sayali Chandrashekhar Deolankar Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Shashanka G Koyangana Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Arun H Patil Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Yashwanth Subbannayya Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Prashant Kumar Modi Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • T S Keshava Prasad Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.

DOI:

https://doi.org/10.31117/neuroscirn.v5i2.153

Keywords:

Post-translational modification, Alzheimer’s disease, multi-OMICS, proteomics, PTM biology, bioinformatics

Abstract

This article describes the data obtained for global post-translational modifications (PTMs) profiled for Alzheimer's Disease (AD) from two distinct human brain regions and one cerebrospinal fluid (CSF) sample. The PTM profiling was performed to identify phosphorylation, O-GluNAcetylation, methylation, acetylation and citrullination using three publicly available LC-MS/MS raw data sets (PRIDE ID: PXD004010, PXD002516, PXD004863). A total of 1,857 PTM harbouring proteins with 4,961 unique post-translationally modified peptides were identified. Among the modified peptides, 75 corresponded uniquely to proteins identified from CSF samples. The data is related to the research article "Dissecting Alzheimer's disease molecular substrates by proteomics and discovery of novel post-translational modifications (PTMs)".

Author Biographies

Sayali Chandrashekhar Deolankar, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.

Graduate (Ph.D.) Student

T S Keshava Prasad, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.

Professor and Deputy Director

References

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Published

2022-06-10

How to Cite

Deolankar, S. C., Koyangana, S. G., Patil, A. H., Subbannayya, Y., Modi, P. K. and Prasad, T. S. K. (2022) “Data on multiple post-translational modifications in Alzheimer’s disease”, Neuroscience Research Notes, 5(2), p. 153. doi: 10.31117/neuroscirn.v5i2.153.