Impact of rhythmic auditory stimulation on gait disturbances in individuals with progressive supranuclear palsy
DOI:
https://doi.org/10.31117/neuroscirn.v9i1.495Keywords:
Progressive supranuclear palsy, Auditory processing, Gait training, Balance, MobilityAbstract
The neurological disorder known as Progressive Supranuclear Palsy, or PSP, is characterized by severe difficulties in movement and balance, which frequently result in falls and a decrease in function. Sensory cueing techniques such as Auditory Stimulation and visual stimulation that utilizes external cues to enhance motor coordination and gait performance in movement disorders. Sixty people with a diagnosis of progressive supranuclear palsy (PSP) were chosen by convenience sampling and split up into two groups: thirty in the experimental group received balance exercises and rhythmic auditory stimulation, while thirty in the control group received balance training and visual cueing. Over a six-week period, both therapies were given for 40 minutes, five days a week. Before and after the intervention, gait performance was evaluated using the 10-Meter Walk Test and the Timed Up and Go (TUG) Test. The Timed Up and Go (TUG) Test and the 10-Meter Walk Test showed statistically significant improvements in the Rhythmic Auditory Stimulation (RAS) group as compared to the visual cueing group (P-value <0.0001). By encouraging better health outcomes through non-invasive rehabilitation, this research supports good health and well-being. It also reduces inequality by ensuring that people with neurodegenerative illnesses have fair access to effective rehabilitation. In conclusion, rhythmic auditory stimulation significantly improves gait speed and motility in individuals with progressive supranuclear palsy (PSP) when paired with balance training.
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Adam, H., Gopinath, S. C. B., Adam, T., Salim, E. T., & Fakhri, M. A. (2025). Impaired striatum dopamine release in parkinson’s disease. Current Medicinal Chemistry, 32(34), 7554–7559. https://doi.org/10.2174/0109298673356301250130074521
Agarwal, S., & Gilbert, R. (2025). Progressive supranuclear palsy. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK526098/
Ali, F., Martin, P. R., Botha, H., Ahlskog, J. E., Bower, J. H., Masumoto, J. Y., Maraganore, D., Hassan, A., Eggers, S., Boeve, B. F., Knopman, D. S., Drubach, D., Petersen, R. C., Dunkley, E. D., Van Gerpen, J., Uitti, R., Whitwell, J. L., Dickson, D. W., & Josephs, K. A. (2019). Sensitivity and specificity of diagnostic criteria for progressive supranuclear palsy. Movement Disorders, 34(8), 1144–1153. https://doi.org/10.1002/mds.27619
Amano, S., Skinner, J. W., Lee, H. K., Stegemöller, E. L., Hack, N., Akbar, U., Vaillancourt, D., McFarland, N. R., & Hass, C. J. (2015). Discriminating features of gait performance in progressive supranuclear palsy. Parkinsonism & Related Disorders, 21(8), 888–893. https://doi.org/10.1016/j.parkreldis.2015.05.017
Amboni, M., Iuppariello, L., Iavarone, A., Fasano, A., Palladino, R., Rucco, R., Picillo, M., Lista, I., Varriale, P., Vitale, C., Cesarelli, M., Sorrentino, G., & Barone, P. (2018). Step length predicts executive dysfunction in Parkinson’s disease: a 3-year prospective study. Journal of Neurology, 265(10), 2211–2220. https://doi.org/10.1007/s00415-018-8973-x
Blood, A. J., & Zatorre, R. J. (2001). Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proceedings of the National Academy of Sciences, 98(20), 11818–11823. https://doi.org/10.1073/pnas.191355898
Bluett, B., Litvan, I., Cheng, S., Juncos, J., Riley, D. E., Standaert, D. G., Reich, S. G., Hall, D. A., Kluger, B., Shprecher, D., Marras, C., & Jankovic, J. (2017). Understanding falls in progressive supranuclear palsy. Parkinsonism & Related Disorders, 35, 75–81. https://doi.org/10.1016/j.parkreldis.2016.12.009
Brown, F. S., Rowe, J. B., Passamonti, L., & Rittman, T. (2020). Falls in progressive supranuclear palsy. Movement Disorders Clinical Practice, 7(1), 16–24. https://doi.org/10.1002/mdc3.12879
Clerici, I., Ferrazzoli, D., Maestri, R., Bossio, F., Zivi, I., Canesi, M., Pezzoli, G., & Frazzitta, G. (2017). Rehabilitation in progressive supranuclear palsy: effectiveness of two multidisciplinary treatments. PLoS ONE, 12(2), e0170927. https://doi.org/10.1371/journal.pone.0170927
De Dreu, M. J., Van Der Wilk, A. S. D., Poppe, E., Kwakkel, G., & Van Wegen, E. E. H. (2012). Rehabilitation, exercise therapy and music in patients with Parkinson’s disease: a meta-analysis of the effects of music-based movement therapy on walking ability, balance and quality of life. Parkinsonism & Related Disorders, 18, S114–S119. https://doi.org/10.1016/S1353-8020(11)70036-0
De Vos, M., Prince, J., Buchanan, T., FitzGerald, J. J., & Antoniades, C. A. (2020). Discriminating progressive supranuclear palsy from Parkinson’s disease using wearable technology and machine learning. Gait & Posture, 77, 257–263. https://doi.org/10.1016/j.gaitpost.2020.02.007
Deepa, P., & Khilar, R. (2025). A novel stacked ensemble classifier for Parkinson’s disease classification using voice features. Proceedings of the Indian National Science Academy, 91(1), 109–119. https://doi.org/10.1007/s43538-024-00365-z
Devi, S. V. A., Vijayalakshmi, K., Krishnan, R. S., Raj, J. R. F., Umesh, R., & Soundiraraj, N. (2025). Hybrid deep learning methods for enhancing Parkinson’s disease early detection. 2025 4th International Conference on Sentiment Analysis and Deep Learning (ICSADL), 1462–1469. https://doi.org/10.1109/ICSADL65848.2025.10933259
Dickson, D. W. (1999). Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology, 246(S2), II6–II15. https://doi.org/10.1007/BF03161076
Goetz, C. G., Leurgans, S., Lang, A. E., & Litvan, I. (2003). Progression of gait, speech and swallowing deficits in progressive supranuclear palsy. Neurology, 60(6), 917–922. https://doi.org/10.1212/01.WNL.0000052686.97625.27
Grimm, M., Respondek, G., Stamelou, M., Arzberger, T., Ferguson, L., Gelpi, E., Giese, A., Grossman, M., Irwin, D. J., Pantelyat, A., Rajput, A., Roeber, S., Van Swieten, J. C., Troakes, C., Antonini, A., Bhatia, K. P., Colosimo, C., Van Eimeren, T., Kassubek, J., … for the Movement Disorder Society‐endorsed PSP Study Group. (2019). How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy. Movement Disorders, 34(8), 1228–1232. https://doi.org/10.1002/mds.27666
Jayasudha, V., Deepa, N., & T, D. (2025). Fuzzy relevance vector machine-based segmentation and adaptive network-based fuzzy inference systems for Parkinson’s disease detection and classification. Discover Computing, 28(1), 58. https://doi.org/10.1007/s10791-025-09534-0
Koga, S., Kouri, N., Walton, R. L., Ebbert, M. T. W., Josephs, K. A., Litvan, I., Graff-Radford, N., Ahlskog, J. E., Uitti, R. J., Van Gerpen, J. A., Boeve, B. F., Parks, A., Ross, O. A., & Dickson, D. W. (2018). Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype. Acta Neuropathologica, 136(3), 389–404. https://doi.org/10.1007/s00401-018-1878-z
Nicolai, S., Mirelman, A., Herman, T., Zijlstra, A., Mancini, M., Becker, C., Lindemann, U., Berg, D., & Maetzler, W. (2010). Improvement of balance after audio-biofeedback: a 6-week intervention study in patients with progressive supranuclear palsy. Zeitschrift Für Gerontologie Und Geriatrie, 43(4), 224–228. https://doi.org/10.1007/s00391-010-0125-6
Nombela, C., Hughes, L. E., Owen, A. M., & Grahn, J. A. (2013). Into the groove: can rhythm influence Parkinson’s disease? Neuroscience & Biobehavioral Reviews, 37(10), 2564–2570. https://doi.org/10.1016/j.neubiorev.2013.08.003
Ohara, M., Hirata, K., Matsubayashi, T., Chen, Q., Shimano, K., Hanazawa, R., Hirakawa, A., Yokota, T., & Hattori, T. (2024). Circular walking is useful for assessing the risk of falls in early progressive supranuclear palsy. Journal of Neurology, 271(9), 6349–6358. https://doi.org/10.1007/s00415-024-12551-6
Perera, S., Mody, S. H., Woodman, R. C., & Studenski, S. A. (2006). Meaningful change and responsiveness in common physical performance measures in older adults. Journal of the American Geriatrics Society, 54(5), 743–749. https://doi.org/10.1111/j.1532-5415.2006.00701.x
Sharma, M., Mishra, R. K., Hall, A. J., Casado, J., Cole, R., Nunes, A. S., Barchard, G., Vaziri, A., Pantelyat, A., & Wills, A.-M. (2023). Remote at-home wearable-based gait assessments in progressive supranuclear palsy compared to Parkinson’s disease. BMC Neurology, 23(1), 434. https://doi.org/10.1186/s12883-023-03466-2
Sivalingam, A. M., & Sureshkumar, D. D. (2025). Exosomes in regulating miRNAs for biomarkers of neurodegenerative disorders. Molecular Neurobiology, 62(6), 7576–7596. https://doi.org/10.1007/s12035-025-04733-8
Steffen, T. M., Boeve, B. F., Petersen, C. M., Dvorak, L., & Kantarci, K. (2014). Long-term exercise training for an individual with mixed corticobasal degeneration and progressive supranuclear palsy features: 10-year case report follow-up. Physical Therapy, 94(2), 289–296. https://doi.org/10.2522/ptj.20130052
Thaut, M. H., McIntosh, G. C., Rice, R. R., Miller, R. A., Rathbun, J., & Brault, J. M. (1996). Rhythmic auditory stimulation in gait training for Parkinson’s disease patients. Movement Disorders, 11(2), 193–200. https://doi.org/10.1002/mds.870110213
Zadikoff, C., & Lang, A. E. (2005). Apraxia in movement disorders. Brain, 128(7), 1480–1497. https://doi.org/10.1093/brain/awh560
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Copyright (c) 2026 Priyadharshini Kumar, Nijidha Manshi, Vignesh Srinivasan, Sathya Siva, Ahalya S
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