A mini review on genes in stroke recovery: unveiling the genetic blueprint for rehabilitation therapies

Authors

  • Nurhaziqah binti Ramlan Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.
  • Eric Tzyy Jiann Chong Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.

DOI:

https://doi.org/10.31117/neuroscirn.v8i4.476

Keywords:

Stroke recovery, Genetic factors, Prognostic biomarkers, Rehabilitation therapies

Abstract

Stroke remains a significant global cause of death and long-term disability, categorized into hemorrhagic stroke, ischemic stroke, and transient ischemic attack. Recovery outcomes can vary greatly, often influenced by genetic factors. This review highlights key genes involved in stroke recovery, including brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), C-X-C motif chemokine ligand 12 (CXCL12), hypoxia-inducible factor 1-alpha (HIF1A), nuclear factor erythroid 2-related factor 2 (NRF2), nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3), sirtuin 1 (SIRT1), and tissue inhibitor of metalloproteinase 3 (TIMP3). These genes play important roles in neurotrophic support and neuronal survival, angiogenesis, inflammation and immune modulation, and extracellular matrix remodeling after stroke. Insights from both human and animal studies underscore the potential of these genetic markers as prognostic indicators and therapeutic targets for stroke recovery. Understanding these factors may lead to more personalized rehabilitation strategies, and future research is needed to explore gene-environment interactions and translate genetic findings into effective stroke recovery therapies.

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2025-12-29

How to Cite

Ramlan, N. binti, & Chong, E. T. J. (2025). A mini review on genes in stroke recovery: unveiling the genetic blueprint for rehabilitation therapies. Neuroscience Research Notes, 8(4), 476.1–476.12. https://doi.org/10.31117/neuroscirn.v8i4.476

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Vol. 8 No. 4 (2025): Regular Issue

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Mini-Review

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