Insights of the pathophysiology of neurodegenerative diseases and the role of phytochemical compounds in its management


  • Zurina Hassan Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia
  • Raghava N. Sriramaneni Department of Human Oncology, University of Wisconsin, Wisconsin, USA.



Neurodegenerative disease, Alzheimer’s Disease, Parkinson’s Disease, active compounds, pathophysiology


A neurodegenerative disease (ND) is defined as an irreversible disorder in most cases, leading to progressive loss of neurons and intellectual abilities. ND can lead to fatality in most circumstances, and the elderly above the age of sixty-five (65) constitute the major risk category. The most common type of ND includes Alzheimer's disease (AD), and Parkinson's disease (PD). Other NDs are Huntington's disease (HD), motor neuron disease (MND), spinocerebellar ataxia (SCA), spinal muscular atrophy (SMA), and prion disease. ND strikes mainly in the middle to late life incidence expected to rise as the population ages.


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How to Cite

Hassan, Z. and Sriramaneni, R. N. (2021) “Insights of the pathophysiology of neurodegenerative diseases and the role of phytochemical compounds in its management”, Neuroscience Research Notes, 4(3), pp. 1–10. doi: 10.31117/neuroscirn.v4i3.77.