Dopamine transporter 1 (DAT1) rs40184 single nucleotide polymorphism is not associated with the Malaysian major depressive disorder subjects

  • Asraa Faris Aldoghachi Department of Biomedical Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Pike-See Cheah Department of Human Anatomy, University Putra Malaysia, Serdang, Selangor, Malaysia.
  • Normala Ibrahim Department of Psychiatry, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Munn Sann Lye Department of Community Health, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • King-Hwa Ling Department of Biomedical Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Keywords: Major depressive disorder, DAT1, rs40184, high-resolution melting, ppolymerase chain reaction

Abstract

Major depressive disorder (MDD) is a serious mental illness with a multifactorial aetiology that was shown to influence behaviour and affect cognition. Previous research has favoured the involvement of dopamine in the aetiology of the disorder, and since one of the critical regulators of the dopamine levels and activity in the brain is DAT1, the present study investigated the association of a single nucleotide polymorphism in the DAT1 gene (rs40184) and MDD in the Malaysian population. A total of 300 cases and 300 matched controls were recruited from four Klang valley hospitals and were screened for DAT1 rs40184 using high resolution melting assays. The allele and genotype frequencies were analysed by using Chi-square. Hardy Weinberg equilibrium for the distribution of alleles and genotypes was tested by using Chi-square. Determination of the association between rs40184 and MDD was achieved by conditional logistic regression using SPSS. In the present study, no significant association was obtained between DAT1 and MDD in the Malaysian population.

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Published
2019-12-04
How to Cite
Aldoghachi, A. F., Cheah, P.-S., Ibrahim, N., Lye, M. S. and Ling, K.-H. (2019) “Dopamine transporter 1 (DAT1) rs40184 single nucleotide polymorphism is not associated with the Malaysian major depressive disorder subjects”, Neuroscience Research Notes, 2(4), pp. 5-13. doi: 10.31117/neuroscirn.v2i4.36.
Section
Research Notes