Platelets as mediators of neuropsychiatric and neurodegenerative diseases

Authors

  • Vasiliki Konstantinidou Department of Biomedical Sciences, School of Health Sciences International Hellenic University, Thessaloniki, Greece
  • Dimitra Farmaki Department of Biomedical Sciences, School of Health Sciences International Hellenic University, Thessaloniki, Greece
  • Ioannis Chonianakis Department of Biomedical Sciences, School of Health Sciences International Hellenic University, Thessaloniki, Greece
  • Kallimachos Gratsos Faculty of Medicine, Sofia Medical School, Sofia, Bulgaria

DOI:

https://doi.org/10.31117/neuroscirn.v7i3.349

Keywords:

Platelets, Neuroinflammation, Neurodegenerative diseases, Neuropsychiatric disorders

Abstract

Numerous studies showing platelets' role in mechanisms beyond hemostasis have sparked interest in investigating all the pathways in which they may be involved. A growing body of evidence indicates that platelets play a key role in immune response. Platelets carry various membrane receptors and release many bioactive molecules that recruit and activate immune cells. Consequently, platelets have a significant immunoregulatory role in infectious, inflammatory, and degenerative diseases. Moreover, immune cells contribute to neuronal development, neural plasticity, and neuroglial activation. The interaction between platelets and immune cells reveals an additional regulatory mechanism of brain function. This review explores the relationship between platelets and the central nervous system (CNS). It highlights the role of platelets in the development of severe neurodegenerative and neuropsychiatric diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS) and depression.

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2024-09-15

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Konstantinidou, V., Farmaki, D., Chonianakis, I. and Gratsos, K. (2024) “Platelets as mediators of neuropsychiatric and neurodegenerative diseases”, Neuroscience Research Notes, 7(3), pp. 349.1–349.15. doi: 10.31117/neuroscirn.v7i3.349.

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Vol. 7 No. 3 (2024): Regular Issue

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Copyright (c) 2024 Vasiliki Konstantinidou, Dimitra Farmaki, Ioannis Chonianakis, Kallimachos Gratsos

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